Genetic birth defects caused by errors in an entire chromosome or part of a chromosome, rather than in a single gene.

What it's like for me: Turner syndrome

Kylie tells 'Big Picture' about her life with Turner syndrome, a chromosome disorder that is thought to affect 3000 women and girls in the UK. 10/12/09

What it's like for me: androgen insensitivity syndrome

A 25-year old female shares her experiences of living with an intersex condition. Born a woman, she carries XY, not XX, sex chromosomes. 10/12/09

Angelman syndrome problems rescued

Research in mice suggests that many of the deficits associated with Angelman syndrome could be alleviated. 08/02/07

Chromosome engineering: extra help

Geneticists have managed to transplant most of human chromosome 21 into mice to produce an animal model of Down's syndrome. 23/09/05

Down's syndrome

A disorder caused by an extra copy of chromsome 21. 15/06/04

Economic evaluation of prenatal diagnosis for chromosomal abnormalities

Should prenatal diagnostic testing be offered to all pregnant women on economic grounds? 29/01/04

Chromosome abnormalities

Chromosome abnormalities involve the gain, loss or rearrangement of visible amounts of genetic material. 24/06/03