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News
Mutations in the UTX gene have been found in many different types of cancer - including kidney cancer, multiple melanoma and oesophogeal cancer - according to a study funded by the Wellcome Trust. The finding, from researchers on the Cancer Genome Project, offers a new avenue for research that could lead to new cancer treatments. 30/03/09
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The Cancer Genome Project has found mutations in 120 kinase genes that appear to 'drive' cancer. 14/03/07
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Researchers from four continents announced the launch of the International Cancer Genome Consortium (ICGC), a major collaboration designed to identify the key genetic mutations involved in up to 50 types of cancer. 29/04/08
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Women who inherit one damaged copy of the PALB2 gene have double the risk of developing breast cancer, and children who inherit two damaged copies have a newly identified serious disorder linked to childhood tumours. 19/02/07
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A woman is pregnant with what is thought to be the first child in the UK to have been selected to be free of a cancer gene, The Times has reported. 15/05/06
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A new international phase II clinical trial is to look at the effect of a novel form of drug treatment for metastatic hereditary breast cancer. 02/05/06
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Lung tumours are found to become resistant to two drugs when they acquire a new genetic mutation. 07/03/05
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The Human Fertilisation and Embryology Authority (HFEA) has approved the screening of embryos, using pre-implantation genetic diagnosis, for familial adenomatous polyposis, an inherited bowel cancer. 02/11/04
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Inheriting the wrong version of a gene called CHEK2 doubles a woman's risk of developing breast cancer, Cancer Research UK scientists have confirmed. 17/05/04
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Features
Small-molecule drug used to treat chronic myeloid leukaemia. 19/04/04
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An RNA molecule that can inhibit the growth of new blood vessels around tumours. 19/04/04
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The report 'Securing Good Health for the Whole Population', by Government adviser Derek Wanless has been published. 26/02/04
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A therapeutic antibody used to treat advanced breast cancer. 04/02/04
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DNA arrays can be used to classify different types of cancer that may be difficult to distinguish by other methods. 27/08/03
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Predicting therapeutic response in breast cancer patients. 13/08/03
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A common variant of the Aurora2 gene may increase susceptibility to cancer development – one of the first examples of a 'low penetrance' tumour susceptibility gene in humans. 24/07/03
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DNA microarrays ('chips') have been used to identify a gene expression 'signature' that can distinguish non-metastatic primary tumours both from metastatic tumours and from primary tumours that are destined to metastasise. 21/03/03
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Features
Large-scale protein analysis can identify cancer-related proteins that can be used as diagnostic markers and perhaps as targets for drug development. 02/02/03
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A new Government advisory committee report looks at the interaction between genes, environmental chemicals and cancer. 11/07/02
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The Cancer Genome Project has identified a major genetic change involved in 70 per cent of cases of malignant melanoma. 09/06/02
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Two studies find that removal of the ovaries reduces cancer risk in BRCA mutation carriers. 31/05/02
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Background
Mutations in several different types of genes are involved in cancer. Some of these genes control growth, or stop excessive growth, while others control a cell's blood supply or its position in the body. 08/06/00
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Background
The transition from a normal cell to a malignant cancer is driven by changes to the cell's DNA. 08/06/00
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