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Genes and disease

Genes can have a powerful impact on our health, sometimes directly - through chromosome or single gene disorders - or by influencing our susceptibility to disease.

Features

Image for Meds behaving badly: Exploring serious drug side-effects
Many common drugs can have harmful side-effects. The Serious Adverse Events Consortium is working to understand the genetic background to these reactions. 13/10/09
Image for Sound science: Exploring the genetics of hearing loss
Progressive hearing loss is a common and debilitating problem in humans, yet relatively little is known about the hundreds of genes thought to be involved. Professor Karen Steel's work work with mice is shedding light on the complex process of hearing. 14/04/09
Image for Gut reaction: Investigating coeliac disease
Professor David van Heel is at the cutting edge of research into coeliac disease, a common and debilitating condition with no cure. We spoke to him and other leading figures in the field to find out what is known about the causes and treatment of this disease. 07/04/09
Image for New genetic variants involved in common diseases
The Wellcome Trust Case Control Consortium publishes its findings on the genetic basis of a number of key diseases. 02/08/07
Image for Trouble in the powerhouse
Mitochondria and human disease. 01/08/07
Image for Fear factor: The genetics of anxiety
Exploring the genetics of anxiety. 20/04/07
Image for Study guide: genetic studies help link genes to disease
How different types of genetic study help link genes to human disease. 20/12/06
Image for Dissecting diabetes: The genetic basis of a complex disease
Many people with diabetes face a lifetime of insulin injections. But Andrew Hattersley's team in Exeter has found that some people with a purely genetic form of diabetes can take tablets instead, transforming their lives. 15/09/05
Image for Diabetes susceptibility genes, part 1: The search for genes
Diabetes is a complex disease, and the search for genes is not straightforward, as Fernando Gibson and Philippe Froguel discuss. 21/04/05
Image for Diabetes susceptibility genes, part 2: Candidate genes
Fernando Gibson and Philippe Froguel discuss studies of 'candidate genes' that may underlie diabetes. 21/04/05
Image for Diabetes susceptibility genes, part 3: Genome-wide searches for type 1 genes
Fernando Gibson and Philippe Froguel examine genome-wide searches for type 1 diabetes susceptibility genes. 21/04/05
Image for Diabetes susceptibility genes, part 4: Genome-wide searches for type 2 genes
Fernando Gibson and Philippe Froguel turn their attention to genome-wide searches for type 2 diabetes genes. 21/04/05
Image for Diabetes susceptibility genes, part 5: Animal models of diabetes
Fernando Gibson and Philippe Froguel conclude their five-part series on diabetes genes with a look at animal models of the disease. 21/04/05
Image for Left-right heart: Genes that control the asymmetry of the heart
Shoumo Bhattacharya is investigating the genes that control heart development and underlie congenital heart defects. 22/02/05
Image for Sound research: The genetics of deafness
Karen Steel is investigating the genes involved in hearing impairment and deafness. 16/12/04
Image for Learning about learning disability
Linking genes to learning difficulties. 16/11/04
Image for Are reports of 'gene X for disease Y' always correct?
Studies claiming that a particular genetic variant is associated with a disease should be viewed with caution, as John Pickrell reports. 19/04/04
Image for Type 1 diabetes and the insulin VNTR allele
A variable region of DNA near to the insulin gene has a marked influence on the risk of getting type 1 diabetes. 08/03/04
Image for 'Selfish' sperm: FGFR2 and embryo development
Rare mutations may be giving sperm cells a selective advantage, even though they cause damage to offspring. 09/10/03
Image for Inside infertility: The Y chromosome
Deletions in the Y chromosome can lead to infertility. Mark Jobling is turning to fertile men to find out why such deletions occur. 09/10/03
Image for Old disease, new insight: Dyskeratosis congenita
Discovery of a link between two genes responsible for a rare inherited disease, dyskeratosis congenita, is shedding light on the biology of ageing and cancer. 28/04/03
Image for Malaria versus the human genome
Variations in human genes influence susceptibility to malaria. Dominic Kwiatkowski discusses key discoveries and hopes for the future. 04/09/02
Image for Human genes and infectious diseases
Variations in the human genome are associated with differing susceptibilities to infectious diseases. 27/08/02
Image for Growing pains: Investigating skeleton disorders
The human genome sequence is proving a boon to researchers investigating disorders of the skeleton. 02/05/02
Image for The enemies within: The origins of the Cancer Genome Project
Led by Michael Stratton, the Cancer Genome Project is systematically searching for genes involved in cancer. 01/03/02
About 6000 known single gene disorders affect humans.
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