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A study has identified a new genetic variant which affects susceptibility to diseases such as tuberculosis and leprosy. 05/03/10
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Scientists have identified new mutations behind the most common type of kidney cancer. This could ultimately help in diagnosis and treatment. 07/01/10
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New genetic clues to the development of type 2 diabetes will aid studies to understand the biology of disease and the search for treatments. 18/12/09
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Research teams led by the Wellcome Trust Sanger Institute have today revealed the first comprehensive analyses of cancer genomes. 16/12/09
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A Wellcome Trust-funded study is the first to show that the loss of a key segment of DNA can lead to severe childhood obesity. 07/12/09
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Two of the largest ever genetic studies of inflammatory bowel diseases have identified genetic regions which increase susceptibility to these conditions. 16/11/09
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A rare form of testicular tumour has provided scientists with new insights into how genetic mutations arise in children. 26/10/09
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The largest ever genome-wide association study of Alzheimer's has uncovered two genes associated with the disease, which will help develop new treatments. 09/09/09
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Genetic variants that increase the risk of developing glioma have been identified by scientists part-funded by the Wellcome Trust. 06/07/09
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A genetic marker that may predict why some individuals suffer liver injury after taking certain medicines is the first finding from the International Serious Adverse Event Consortium. 03/06/09
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The first genetic variants associated with increased risk of testicular cancer have been found in a study part-funded by the Wellcome Trust. 01/06/09
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Nine new genes associated with learning disabilities have been identified in research part-funded by the Wellcome Trust. 24/04/09
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Mutations in the UTX gene have been found in many different types of cancer - including kidney cancer, multiple melanoma and oesophogeal cancer - according to a study funded by the Wellcome Trust. The finding, from researchers on the Cancer Genome Project, offers a new avenue for research that could lead to new cancer treatments. 30/03/09
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Rare genetic mutations that confer protection against developing type 1 diabetes have been found. Furthermore, the nature of the mutations suggests that the disease may be caused by a common virus. 06/03/09
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A European research collaboration has identified a new genetic cause for primary ovarian insufficiency, a condition that can lead to infertility in women. 26/02/09
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Data from the Wellcome Trust Case Control Consortium (WTCCC) have helped uncover ten new genes linked with heart disease. 09/02/09
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Researchers have found evidence that a direct interaction between vitamin D and a common genetic variant alters the risk of developing multiple sclerosis (MS). 06/02/09
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One in a hundred people carry a genetic mutation almost guaranteed to lead to heart problems, research published today in 'Nature Genetics' shows. According to an international team of 25 scientists from four countries, this mutation is carried by one in 25 people from the Indian subcontinent. 19/01/09
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Research part-funded by the Wellcome Trust has revealed a common genetic origin of type 1 diabetes and coeliac disease. 12/12/08
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Scientists at the Wellcome Trust Sanger Institute have developed a new method to screen thousands of gene mutations for their ability to cause cancer. The system will speed up the hunt for the most important mutations in tumour samples and accelerate the identification of new therapeutic targets. 02/12/08
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The Wellcome Trust is to coordinate studies of different subtypes of breast cancer, as part of an international collaboration creating a clearer picture of the genomic changes involved in cancer. 19/11/08
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The Wellcome Trust is seeking new proposals for its genome-wide association studies in disease initiative, building on the success of the Wellcome Trust Case Control Consortium. 11/11/08
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Scientists have identified the first gene that is associated with a common childhood language disorder, known as specific language impairment (SLI). The gene - CNTNAP2 - has also been recently implicated in autism, and could represent a crucial genetic link between the two disorders. 05/11/08
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Researchers have identified a mutant mouse that provides new clues to the genetic cause of progressive hearing loss in humans. 04/11/08
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Scientists have identified one of the genes implicated in age-related macular degeneration, the most common cause of blindness in developed countries. 07/10/08
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New research published has provided fresh insights into the genetics of schizophrenia, particularly highlighting the role of rare copy number variations (CNVs) in causing the disease. The researchers hope the findings will help end some of the stigma surrounding the disease. 31/07/08
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New research has trebled the number of genetic regions known to be implicated in Crohn's, a form of inflammatory bowel disease, to over 30. 29/06/08
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An international team of researchers has identified two genes that play a key role in the risk of osteoporosis. 13/05/08
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Researchers from four continents announced the launch of the International Cancer Genome Consortium (ICGC), a major collaboration designed to identify the key genetic mutations involved in up to 50 types of cancer. 29/04/08
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The largest ever study of genetics of common diseases has been launched with £30 million funding from the Wellcome Trust. 20/04/08
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An international collaboration of scientists from Europe and the US has identified six new genes that play a role in the development of type 2 diabetes. 30/03/08
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Understanding how the genetic make-up of both the patient and the pathogen interact may be essential for allowing us to develop more sophisticated treatments and vaccines. 28/03/08
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Scientists have shown for the first time how a particular family of diseases are passed down from mother to child and how this can lead to the severity of the disease differing widely. 27/01/08
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Research funded by the Wellcome Trust and the Arthritis Research Campaign has identified two genes implicated in the disease ankylosing spondylitis. 21/10/07
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An international research team has discovered a gene that, when mutated, causes one of the most common forms of inherited blindness in babies. 11/06/07
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The Wellcome Trust Case Control Consortium publishes its findings. 11/06/07
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Variants in three genes predispose people to type 2 diabetes. 27/04/07
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Studies of human tumour cells implanted in mice show that abnormal activation of four genes drives the spread of breast cancer to the lungs. 11/04/07
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People with the ApoE4 gene are at higher risk for developing Alzhiemer's disease. 10/04/07
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A gene providing protection against infectious diseases such as malaria can also increase the risk of disease. 29/03/07
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Disrupt the gene that regulates biological clocks in mice and they become manic, exhibiting behaviours similar to humans with bipolar disorder. 19/03/07
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The Cancer Genome Project has found mutations in 120 kinase genes that appear to 'drive' cancer. 14/03/07
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Women who inherit one damaged copy of the PALB2 gene have double the risk of developing breast cancer, and children who inherit two damaged copies have a newly identified serious disorder linked to childhood tumours. 19/02/07
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Variations in a gene known as SORL1 may be a factor in the development of late onset Alzheimer's disease, an international team of researchers has discovered. 16/02/07
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Researchers have found gene mutations that cause trichotillomania, a psychiatric disorder that triggers people to compulsively pull their hair. 27/09/06
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The SUMO1 gene, when underexpressed, can cause cleft lip and palate, one of the world's most common birth defects. 21/09/06
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A global survey of serious genetic conditions has reported that almost eight million children worldwide are born with a serious genetic defect each year. 08/02/06
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Largest twin study ever undertaken confirms highest estimates of genetic risk. 06/02/06
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The nature of the genetic influence on autism is unclear. Now, a possible susceptibility gene links the condition to the brain's serotonin pathways. 05/01/06
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Geneticists have managed to transplant most of human chromosome 21 into mice to produce an animal model of Down's syndrome. 23/09/05
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Three studies find a genetic link to the leading cause of blindness among the over 60s. 15/03/05
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People with more copies of a gene that helps to fight HIV may be less likely to become infected with the virus or to develop AIDS. 06/01/05
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US study finds significant interest in APOE4 testing among adult children of individuals affected by Alzheimer's. 30/07/04
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A natural mutation of a gene that helps regulate the reactivity of the immune system is found to be a major contributor to type 1 diabetes. 12/07/04
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Mutation in the pathway from the insulin receptor leads to insulin resistance and diabetes in some people. 28/05/04
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Inheriting the wrong version of a gene called CHEK2 doubles a woman's risk of developing breast cancer, Cancer Research UK scientists have confirmed. 17/05/04
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An unusual three-stranded DNA structure that forms during replication may underlie neurological diseases such as Friedreich's ataxia. 10/04/04
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International research teams find variants in the HNF4A gene that may predispose people to type 2 diabetes, the most common form of the disease. 11/03/04
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Icelandic researchers identify two variants of the ALOX5AP gene that may increase the risk of heart attack and stroke. 10/02/04
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No obesity or diabetes for a mouse engineered to be immune to a high-fat diet. 02/09/03
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A common variant of the Aurora2 gene may increase susceptibility to cancer development – one of the first examples of a 'low penetrance' tumour susceptibility gene in humans. 24/07/03
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Oxford researchers find gene which predisposes people to asthma and atopy. 19/05/03
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Mutations in a gene called SOX2 may be the cause of a devastating condition that leads to babies being born without eyes. 05/05/03
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Variation in the CTLA-4 gene are associated with increased risk of developing type 1 diabetes, Graves disease and autoimmune hypothyroidism. 30/03/03
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Researchers have discovered how a single genetic mutation triggers heart failure by disrupting the flow of calcium in heart muscle cells. 20/03/03
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Variants of a gene called ADAM33 may be involved in susceptibility to asthma. 13/08/02
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Variants of a gene encoding the protein interleukin 12B may associated with severity of disease in children who have asthma. 02/08/02
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The Cancer Genome Project has identified a major genetic change involved in 70 per cent of cases of malignant melanoma. 09/06/02
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