The genome sequence

How DNA sequencing is uncovering the secrets encoded within the 3 billion nucleotides of the human genome.

Features


	Great expectations: human genome research It's been a decade since the draft human genome sequence was announced. What impact has it had on genetics, genomics and science in general? 24/06/10

	Genomics: The next generation The Human Genome Project and development of faster, cheaper DNA sequencing revolutionised biological research and the technology is still evolving. 28/07/09

	Close cousins Chimps are our closest relatives. Genome sequence comparisons are beginning to identify the key genes that distinguish us from them. 15/01/07

	Painting by numbers Mapping the evolutionary history of genomes. 01/05/06

	The X factor The evolution and biology of the X chromosome. 02/02/06

	Radiation's long-term legacy Radiation can do more than increase your risk of cancer: Yuri Dubrova has found that it can also increase the risk of mutations being passed onto children. 09/10/03

	X and Y chromosomes: Sex and death Is the Y chromosome destined for oblivion? 09/10/03

	The mitochondrial genome Mitochondria, the organelles that produce energy in human cells, have their own DNA. 30/07/03

	Visualising DNA New techniques are providing ever more intimate views of DNA. 21/05/03

	Fred Sanger: Fridge magnate In a remarkable feat of memory, Fred Sanger tracked down the original DNA sample he used in the late 1970s to sequence the human mitochondrial genome. 01/07/02

	John Sulston: Hands-on at the Sanger Under the leadership of Sir John Sulston, the Sanger Centre became one of the world's largest contributors to the Human Genome Project. 28/02/01

	The draft human genome: Y under siege The Y chromosome is a mere stump of a chromosome, with only a few genes. 28/02/01

	The draft human genome: A repetitious genome The human genome is littered with repeat regions. What are they, and where did they come from? 28/02/01

	The draft human genome: At the double Duplications appear to have had a significant role in the evolution of the human genome. 28/02/01

	The draft human genome: Bacterial footprints Bacteria appear to have left their mark on the human genome. 28/02/01

	The draft human genome: Where are all the genes? The draft sequence of the human genome was found to contain many fewer genes than expected. 28/02/01

"The sequence information from the Human Genome Project is like an alphabet. The next step is to figure out the syntax and the grammar." Rick Young

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